![]() ![]() Studies with documented follow-up = 13.3% Oral Care Study Group Systematic Reviews, MASCC/ISOO ComplicationĬT = chemotherapy EORTC QLQ-C30 = European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 HNC = head and neck cancer IMRT = intensity-modulated radiation therapy MASCC/ISOO = Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology RT = radiation therapy VAS = visual analog scale.ĪPain is common in patients with HNCs and is reported by approximately half of patients before cancer therapy, by 81% during therapy, by 70% at the end of therapy, and by 36% at 6 months posttreatment. Prevalence for Oral Complications With Cancer Therapies: Toxicities emerge in the context of specific oral anatomic structures and theirįrequencies of oral complications vary by cancer therapy estimates are included in Table 1. While oral complications may mimic selected systemic disorders, unique oral Thus, a multidisciplinary oncology team that includes oncologists, oncology nurses, and dental generalists and specialists as well as dental hygienists, social workers, dieticians, and related health professionals can often achieve highly effective preventive and therapeutic outcomes relative to oral complications in these patients. In addition, selected cancer patients (e.g., status posttreatment with high-dose head-and-neck radiation) are often at lifelong risk for serious complications such as osteoradionecrosis of the mandible. A multidisciplinary approach is warranted because the medical complexity of these patients affects dental treatment planning, prioritization, and timing of dental care. It is essential that a multidisciplinary approach be used for oral management of the cancer patient before, during, and after cancer treatment. Gastrointestinal tract, this summary focuses on oral complications ofĪntineoplastic drugs and radiation therapies. ![]() Within the oral cavity presumably reflect the changes that occur throughout the Although changes in soft tissue structures The lining mucosa, a diverse and complex microflora, and trauma to oral tissuesĭuring normal oral function. This risk results from multiple factors, including high rates of cellular turnover for The oral cavity is highly susceptible to directĪnd indirect toxic effects of cancer chemotherapy and ionizing radiation. The oral mucosa, is a prime target for treatment-related toxicity by virtue of The mucosal lining of the gastrointestinal tract, including Aggressive treatment of malignant disease may produce unavoidable toxicities
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